| atropine; (RS)-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate | |
| Links: | 🌍 Wikipedia, 📏 NIST, 📖Houben-Weyl, 2. Band (Atropin); p. 475, 528, |
| MeSH: | Adjuvants, Anesthesia; Anti-Asthmatic Agents; Autonomic Agents; Bronchodilator Agents; Central Nervous System Agents; Cholinergic Agents; Cholinergic Antagonists; Muscarinic Antagonists; Neurotransmitter Agents |
| CAS RN: | [51-55-8] |
| Formula: | C17H23NO3; 289.37 g/mol |
| InChiKey: | RKUNBYITZUJHSG-UHFFFAOYSA-N |
| SMILES: | CN1C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 |
| Pharmaceutical use: | analgesic; anthydrotic; anticholinergic; antisialogogue; antispasmodic; bronchodilator; mydriatic; psychoactive |
| Toxicology (LD50): | 31.0 mg/Kg (cat, iv); 140 mg/Kg(cat, sc); 175 mg/Kg(dog, ip); 101.0 mg/Kg(dog, iv); 225 mg/Kg(dog, sc); 1 750 mg/Kg(frog, sc); 400 mg/Kg(guinea~pig, ip); 1 100 mg/Kg(guinea~pig, or); 450 mg/Kg(guinea~pig, sc); 250 mg/Kg(mouse, ip); 91.0 mg/Kg(mouse, iv); 400 mg/Kg(mouse, or); 794 mg/Kg(mouse, or); 1 650 mg/Kg(mouse, or); 400 mg/Kg(mouse, sc); 750 mg/Kg(mouse, sc); 900 mg/Kg(mouse, sc); 220 mg/Kg(pigeon, sc); 70.0 mg/Kg(rabbit, iv); 1 450 mg/Kg(rabbit, or); 262 mg/Kg(rabbit, sc); 675 mg/Kg(rabbit, sc); 280 mg/Kg(rat, ip); 600 mg/Kg(rat, ip); 750 mg/Kg(rat, or); 1 000 mg/Kg(rat, or); 750 mg/Kg(rat, sc); 2 000 mg/Kg(rat, sc) |
| Melting point: | 118 °C |
| Log10 partition octanol / water: | 1.83 |
| 1g dissolves in: 1.46g ethanol; 1.49g diethylamine; 1.56g trichloromethane; 2.94g aniline; 12.50g pyridine; 16.61g diethyl ether; 33.33g 1,2,3-propanetriol; 88.03g tetrachloromethane; 450.45g water | |